(E/Z) -ABP/PPAR modulator 1

ABP/PPAR modulator 1 is an orally active modulator targeting FABP and PPAR, with IC50 values of 0.65 μM and 1.08 μM for FABP1 and FABP4, respectively, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.