MS6076

MS6076 is a mitochondrial protease ClpP activator. It specifically triggers the activation of ClpP protease within the mitochondrial matrix, significantly disrupting the mitochondrial electron transport chain (ETC) by accelerating the degradation of unfolded proteins. MS6076 exhibits strong cytotoxicity against various breast cancer cell lines, including triple-negative breast cancer cells (MDA-MB-468, MDA-MB-231), as well as other subtypes (SK-BR-3, MCF-7, BT-474) . This compound is applicable in breast cancer research.