Topoisomerase I-IN-18

TopoisomeraseI-IN-18, a derivative of Thiosemicarbazide, functions as a Topoisomerase I inhibitor, disrupting DNA synthesis and transcription. It suppresses tumor cell proliferation by inducing S phase cell cycle arrest. Additionally, it enhances mitochondria-mediated apoptosis (apoptosis), evidenced by inhibited cell migration and increased intracellular reactive oxygen species (ROS) . TopoisomeraseI-IN-18 upregulates p53 protein expression, γH2AX phosphorylation, Bax expression, downregulates Bcl-2 expression, and activates the caspase cascade. This compound is applicable for lung cancer research.