Ferroptosis inducer-12

Ferroptosisinducer-12 is a potent and selective inducer of ferroptosis. It demonstrates strong antiproliferative activity against HT1080 and OS-RC-2 cell lines, with IC50 values of 3 nM and 5 nM, respectively. This compound significantly inhibits GPX4 enzyme activity, induces intracellular ROS, and elevates Fe2+ levels within OS-RC-2 cells. Moreover, Ferroptosisinducer-12 markedly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts. It is applicable for cancer research.