Copper ionophore I

Copper ionophore I is an efficient carrier of copper ions that modulates intracellular copper levels to induce cuproptosis, with effects observed in cells such as 4T1 (IC50= 0.45 μM) and MDA-MB-231 (IC50= 1.21 μM) . It elevates ROS, leading to mitochondrial dysfunction, and decreases the expression of proteins FDX1, DLAT, and LIAS. Additionally, it can activate immune-related pathways, enhancing T cell infiltration, making it a valuable compound for cancer research.