LIFR/GPBAR1 modulator 1
LIFR/GPBAR1 modulator 1 is an orally active, potent GPBAR1 agonist (EC50= 0.2 μM) and LIFR inhibitor (IC50= 7.9 μM) . It enhances the expression of leukemia inhibitory factor (LIF) -mediated LIFR and GPBAR1 mRNA, while significantly reducing the expression of fibrosis markers (COL1A1, ASMA, and TGFβ), decreasing TIMP1 levels, and increasing MMP9 expression. LIFR/GPBAR1 modulator 1 is applicable for research into human fibrotic diseases.
Product Specifications
Storage Conditions
-20°C
Notes
For research use only.
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