LW106
LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. It does not inhibit IDO2 and TDO. LW106 suppresses tumor growth by limiting substrate immune crosstalk and enriching cancer stem cells (CSC) within the tumor microenvironment. It reduces CSC subpopulations in xenograft tumors, leading to decreased tumor cell proliferation/invasiveness and inducing apoptosis. LW106 is applicable in research on lung cancer and melanoma.
Product Specifications
CAS Number
2116519-76-5
Smiles
ON=C (C1=NON=C1N) N2CC=3C=CC=CC3C2
Molecular Formula
C11H11N5O2
Molecular Weight
245.24
Storage Conditions
-20°C
Notes
For research use only.
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