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LW106

LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. It does not inhibit IDO2 and TDO. LW106 suppresses tumor growth by limiting substrate immune crosstalk and enriching cancer stem cells (CSC) within the tumor microenvironment. It reduces CSC subpopulations in xenograft tumors, leading to decreased tumor cell proliferation/invasiveness and inducing apoptosis. LW106 is applicable in research on lung cancer and melanoma.

Product Specifications

CAS Number

2116519-76-5

Smiles

ON=C (C1=NON=C1N) N2CC=3C=CC=CC3C2

Molecular Formula

C11H11N5O2

Molecular Weight

245.24

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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