Glucocorticoid receptor/IL-6-IN-1
Glucocorticoid receptor/IL-6-IN-1 (Compound 35) is a selective dual inhibitor of the glucocorticoid receptor (GR) and the IL-6 signaling pathway, with IC50 values of 120 nM and 59 nM, respectively. It suppresses IL-6-induced phosphorylation of JAK/STAT3, thereby blocking the transcription of inflammatory cytokines. This compound holds potential for research into inflammatory diseases such as rheumatoid arthritis and asthma.
Product Specifications
CAS Number
1198784-71-2
Smiles
O=C (N) C1=CC (F) =CC=C1C (C) (C) CC (O) (CC2=CC=3C=C (N=CC3N2) S (=O) (=O) C) C (F) (F) F
Molecular Formula
C22H23F4N3O4S
Molecular Weight
501.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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