IDO1-IN-32

IDO1-IN-32 (Compound 45) is a potent and orally active IDO1 inhibitor with an IC50 of 10 pM. It exhibits significant antiproliferative activity against Hela cells. In CT26 and LCC xenograft mouse models, IDO1-IN-32 significantly suppresses tumor growth by activating antitumor immunity. This compound is useful for studying colon and breast cancers.