MRS4917

MRS4917 is a potent and selective orally active P2Y14 receptor (hP2Y14R) antagonist, with an IC50 of 2.88 nM and a Ki of 1.67 nM, demonstrating over 18,000-fold selectivity against P2Y6R (IC50= 54 μM) . It effectively reverses established mechanical allodynia in a chronic sciatic nerve compression (CCI) mouse model without affecting thermoregulation when administered orally. MRS4917 is applicable for research in neurological disorders.