EP4 receptor antagonist 8
EP4 receptor antagonist 8 is an orally active EP4 receptor antagonist with an IC50 value of 6.40 nM in humans. This compound significantly reduces paw and joint swelling, infiltration of inflammatory cells, cartilage damage, pannus formation, and bone erosion in a dose-dependent manner in arthritis (AIA) mice. EP4 receptor antagonist 8 is useful for research on inflammatory pain.
Product Specifications
CAS Number
3068255-86-4
Smiles
N#CC1=CC=C (NC (=O) NCCN2N=C3C=CC=CC3=C2C (=O) NCC4=CC=C (C=C4) C (=O) O) C (Cl) =C1
Molecular Formula
C26H21ClN6O4
Molecular Weight
516.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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