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EP4 receptor antagonist 8

EP4 receptor antagonist 8 is an orally active EP4 receptor antagonist with an IC50 value of 6.40 nM in humans. This compound significantly reduces paw and joint swelling, infiltration of inflammatory cells, cartilage damage, pannus formation, and bone erosion in a dose-dependent manner in arthritis (AIA) mice. EP4 receptor antagonist 8 is useful for research on inflammatory pain.

Product Specifications

CAS Number

3068255-86-4

Smiles

N#CC1=CC=C (NC (=O) NCCN2N=C3C=CC=CC3=C2C (=O) NCC4=CC=C (C=C4) C (=O) O) C (Cl) =C1

Molecular Formula

C26H21ClN6O4

Molecular Weight

516.94

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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