AP232

AP232 is a selective inhibitor of U2AF1-UHM with an IC50 value of 7.96 μM. It shows 2.8 to 24 times selectivity over other UHM-containing proteins. AP232 exhibits anti-leukemia activity and demonstrates heightened effectiveness in cell lines with splicing factor mutations. It can induce G2/M and G1 phase arrest in leukemia cells, impair lysosomal acidification, and inhibit autophagy (autophagy) . AP232 is applicable in cancer research, particularly for leukemia studies.