AGU661
AGU661 is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) with an IC50 of 0.22 nM. It effectively reduces PGE2 production in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. Despite its poor physicochemical properties, low metabolic stability, and high plasma protein binding rate, encapsulating AGU661 in PLGA-based nanoparticles significantly enhances its bioactivity. AGU661 is applicable for research on inflammatory diseases.
Product Specifications
CAS Number
3038861-75-2
Smiles
O=C (NC=1C=CC (=CC1) C2=NC3=CC=C (C=C3N2) C (F) (F) F) C4=CC (=CC=C4Cl) CNC (=O) C5 (CCC5) C (F) (F) F
Molecular Formula
C28H21ClF6N4O2
Molecular Weight
594.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
AGI1201-100 100 µL
KD-Validated Anti-Calmegin Rabbit Monoclonal Antibody
Sign In for Pricing
View Details 
PROTQ99685-50ug 50 µg
Human Monoglyceride Lipase/MGLL Recombinant Protein
Sign In for Pricing
View Details MBS1029570-01 0.02 mg (E-Coli)
Recombinant Ajellomyces dermatitidis Mitochondrial distribution and morphology protein 12 (MDM12)
Sign In for Pricing
View Details 
MBS1029570-02 0.02 mg (Yeast)
Recombinant Ajellomyces dermatitidis Mitochondrial distribution and morphology protein 12 (MDM12)
Sign In for Pricing
View Details