AGU661

AGU661 is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) with an IC50 of 0.22 nM. It effectively reduces PGE2 production in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. Despite its poor physicochemical properties, low metabolic stability, and high plasma protein binding rate, encapsulating AGU661 in PLGA-based nanoparticles significantly enhances its bioactivity. AGU661 is applicable for research on inflammatory diseases.