Trpvicin

Trpvicin is a potent and subtype-selective TRPV3 inhibitor, exhibiting IC50 values of 0.41 μM for hTRPV3-WT and 0.22 μM for hTRPV3-G573S mutants. It shows only weak inhibitory effects on other TRP family members (such as TRPV1/2/4/5/6, TRPA1, and TRPM8) . By binding to the VSLD-PD site, Trpvicin stabilizes the closed state of TRPV3 channels, and in the G573S mutant, it enters the central cavity, enhancing inhibition through symmetry restructuring and pore blockage. In mouse models, Trpvicin can inhibit itching and hair loss and is applicable for research related to inflammation and immunology.