4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE

4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE is a component of a drug-linker conjugate for ADC. It includes a linker and a biologically active small molecule toxin, MMAE. This compound can conjugate with NN2101 (anti-c-Kit) to form NN3201, which rapidly internalizes and inhibits SCF-driven signal transduction, inducing cell cycle arrest and apoptosis through payload delivery. NN3201 exhibits significant c-Kit-dependent antitumor activity in various tumor models, such as small cell lung cancer (SCLC) and gastrointestinal stromal tumors (GIST) .