Nav1.7-IN-19

Nav1.7-IN-19 is a potent, selective, and orally active Nav1.7 inhibitor with an IC50 value of 0.49 μM. It shows high selectivity for Nav1.7, exhibiting 312-fold and 662-fold selectivity over Nav1.1 and Nav1.5, respectively, in the inactivated state. Nav1.7-IN-19 weakly inhibits the hERG potassium channel. Additionally, Nav1.7-IN-19 possesses analgesic properties, making it useful for neurological disorder research.