α-Glucosidase-IN-98

α-Glucosidase-IN-98 is a potent orally active α-glucosidase inhibitor with an IC50 value of 18.1 μM. It reversibly binds to α-glucosidase through hydrogen bonding, electrostatic interactions, and hydrophobic interactions, inducing significant conformational changes in the enzyme's secondary structure. This compound can reduce postprandial blood glucose levels in mice with starch/sucrose loads and is applicable in research related to type 2 diabetes (T2DM) .