JAK1-IN-19

JAK1-IN-19 (Compound 18) is a potent JAK1 inhibitor with IC50 values of 0.02 nM for JAK1, 0.5 nM for JAK2, 91 nM for JAK3, and 0.2 nM for TYK2. It demonstrates a higher intrinsic clearance in both rats and humans. JAK1-IN-19 is applicable for research into atopic dermatitis and other autoimmune diseases.