Y502-2304

Y502-2304 is a c-MycG-quadruplex stabilizer that exhibits potent antiproliferative activity in multiple myeloma (MM) cells. It downregulates c-Myc mRNA and protein expression and induces apoptosis in MM cells, as characterized by increased γH2AX levels, elevated reactive oxygen species (ROS) production, and mitochondrial dysfunction. Additionally, Y502-2304 significantly inhibits tumor growth in xenograft MM models and is useful for studying multiple myeloma.