Enpp-1-IN-29

Enpp-1-IN-29 (Compound 1) is a highly selective inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) with an IC50 of 0.05 nM. This compound shows potential for research into cancers with overexpressed ENPP1, such as breast cancer, head and neck cancer, and metastatic chromosomal instability tumors, as well as immunological disorders like autoimmune diseases and tumor immune evasion.