TGF-β/Smad-IN-2

TGF-β/Smad-IN-2 is an orally active TGF-β/Smad inhibitor. It suppresses TGF-β-induced differentiation of fibroblasts into myofibroblasts and collagen deposition, with an IC50 value of 102 μM for reducing collagen in LL29 cells. TGF-β/Smad-IN-2 acts by modulating the SMAD3/SMAD7 signaling pathway and decreases lung index in mice with pulmonary fibrosis. This compound is applicable in pulmonary fibrosis research.