PI3K/mTOR-IN-18

PI3K/mTOR-IN-18 (Compound 12) is a highly selective dual inhibitor of PI3K/mTOR. It exerts antitumor effects through competitive binding to PI3Kα (Ki=0.130 nM) and mTOR (Ki=0.111 nM) . By blocking the PI3K/AKT/mTOR pathway, PI3K/mTOR-IN-18 inhibits tumor cell proliferation (IC50=144 nM) and holds potential for research in solid tumors such as breast cancer and non-small cell lung cancer.