AChE-IN-94

AChE-IN-94 is an orally active acetylcholinesterase (AChE) inhibitor capable of crossing the blood-brain barrier, demonstrating an IC50 of 0.40 μM and a Ki of 0.28 μM. It inhibits both spontaneous and AChE-mediated Aβ1-42 aggregation and alleviates cognitive/memory deficits in scopolamine-induced amnesia models. AChE-IN-94 is applicable in Alzheimer's disease (AD) research.