S1P1 agonist 7

S1P1 agonist 7 is a potent and orally active β-arrestin-biased S1P1 agonist [EC50 (G-protein) = 12.7 nM, EC50 (β-arrestin) = 3.23 nM], exhibiting strong immunomodulatory activity and favorable safety. It has excellent metabolic stability, shows weak to moderate CYP inhibition, and demonstrates high selectivity without affecting the S1P3 receptor. In a mouse model of experimental autoimmune encephalomyelitis, S1P1 agonist 7 shows favorable pharmacokinetic properties, effectively reduces circulating lymphocyte counts, and significantly alleviates disease severity. This compound is applicable for research in multiple sclerosis.