COX-2-IN-57

COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. In a rat model with neuropathy induced by Cisplatin/radiation, it reduces MyD88 expression and lowers serum levels of COX-2, PGE2, and COX-1. COX-2-IN-57 demonstrates excellent analgesic effects in hot plate, cold allodynia, and Randall-Selitto tests, and provides liver/kidney protection. It is applicable for inflammation research.