2,5-Epidithia-3,6-dioxopiperazine

2,5-Epidithia-3,6-dioxopiperazine (Formula 15) is a derivative of Epidithiodioxopiperazine (ETP) . It enhances cell permeability and restores the activity of 2-Cys-Prx, especially peroxidase II (PrxII), within stimulated cells. This compound inhibits PDGF-induced proliferation and migration of vascular smooth muscle cells while promoting VEGF-induced endothelial cell growth and movement. Furthermore, 2,5-Epidithia-3,6-dioxopiperazine effectively suppresses the proliferation, migration, and pulmonary metastasis of melanoma cells. It holds potential for research on vascular diseases such as hypertension, angina, and myocardial infarction.