Ferroptosis inducer-10

Ferroptosisinducer-10 is an inducer of ferroptosis, capable of inhibiting the growth of A549 cells with an IC50 value of 0.76 μM. It functions by depleting glutathione (GSH), increasing reactive oxygen species (ROS) and malondialdehyde (MDA), and downregulating glutathione peroxidase 4 (GPX4) expression. Additionally, Ferroptosisinducer-10 induces cell cycle arrest at the G2/M phase and inhibits cell migration. This compound is applicable in cancer research, such as in studies of non-small cell lung cancer.