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CP-99994

CP-99994 is a neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. It prevents colorectal sensitization under conditions of visceral hypersensitivity and reduces acetic acid-induced colorectal sensitization in a bladder-colon cross-sensitization model. CP-99994 also attenuates neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.

Product Specifications

CAS Number

136982-36-0

Smiles

N (CC1=C (OC) C=CC=C1) [C@@H]2[C@@H] (NCCC2) C3=CC=CC=C3

Molecular Formula

C19H24N2O

Molecular Weight

296.41

Storage Conditions

-20°C

Notes

For research use only.

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