Naperiglipron
Naperiglipron (LY3549492) (Example 2) is a glucagon-like peptide-1 receptor (GLP-1R) agonist with an EC50 of 1.14 nM for hGLP-1R. It markedly reduces blood glucose levels in GLP-1R gene knock-in mouse models. Additionally, Naperiglipron inhibits PDE10A1 enzyme activity (IC50: 7.43 μM) and exhibits weak hERG inhibitory activity. This compound is applicable in research on Type II diabetes mellitus (T2DM) and obesity.
Product Specifications
CAS Number
2572566-11-9
Smiles
C (N1C=2C (N=C1CC3=C (F) C=C (C (C) =C3) C=4N=C (OCC5=C (F) C=C (C#N) C=C5) C=CC4) =CC=C (C (O) =O) C2) [C@@H]6CCO6
Molecular Formula
C33H26F2N4O4
Molecular Weight
580.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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