HsClpP activator-2

HsClpP activator-2 is an orally active HsClpP agonist with a KD of 40 nM. It exhibits significant inhibitory effects on small cell lung cancer (SCLC) cells, including H69 (IC50 = 0.17 μM) and H82 (IC50 = 0.19 μM) . This compound disrupts mitochondrial membrane potential (MMP), induces apoptosis (apoptosis), and promotes ROS production in H82 cells. Additionally, HsClpP activator-2 significantly suppresses tumor growth in non-SMC cell xenograft models and is applicable for research in small cell lung cancer (SCLC) .