FLT3-IN-34

FLT3-IN-34 is an FLT3 inhibitor with an IC50 value of 1.4 nM. It inhibits the phosphorylation of FLT3 and downstream signaling molecules AKT and ERK1/2. In FLT3-ITD positive MV4-11 cells, FLT3-IN-34 induces concentration-dependent G0/G1 phase arrest and mild apoptosis (apoptosis) . It exhibits potent antiproliferative activity against FLT3-ITD positive MV4-11 cells (IC50 = 14.95 nM) and MOLM-13 cells (IC50 = 18.5 nM) . FLT3-IN-34 is useful for research on FLT3-positive acute myeloid leukemia (AML) .