HDAC1-IN-11

HDAC1-IN-11 (Compound 6) is an HDAC1 inhibitor with an IC50 of 106.6 nM. It suppresses the expression of Sp1 and RAD51, leading to Caspase-dependent apoptosis. HDAC1-IN-11 exhibits antitumor activity and enhances the sensitivity of Etoposide and Gemcitabine by promoting synergistic cell death in NSCLC through inhibiting homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA double-strand break repair. It is applicable in chemotherapy research for cancers such as NSCLC.