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NLRP3/URAT1-IN-1

NLRP3/URAT1-IN-1 is an orally active dual inhibitor targeting NLRP3 and URAT1, with an IC50 of 3.81 μM. It suppresses IL-1β release in mouse bone marrow-derived macrophages (BMDMs) stimulated by LPS and ATP, with an IC50 of 2.61 μM. Additionally, NLRP3/URAT1-IN-1 decreases serum uric acid (SUA) levels and alleviates liver/kidney injury in mice with acute hyperuricemia (HUA) . This compound is relevant for research on gout and hyperuricemia.

Product Specifications

CAS Number

2994637-53-3

Smiles

O=C (NS (=O) (=O) C=1SC=CC1) C2=CC=3C=CC=CC3N2CC4=CC=C (Br) C=5C=CC=CC54

Molecular Formula

C24H17BrN2O3S2

Molecular Weight

525.44

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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