THR-β agonist 11
THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. It demonstrates robust cholesterol-lowering effects in cholesterol-fed rats. In a high-fat diet-carbon tetrachloride (HFD-CCl4) induced model of metabolic dysfunction-associated steatohepatitis (MASH) in mice, THR-β agonist 11 significantly reduces serum total triglycerides (TG), low-density lipoprotein cholesterol (LDL-cholesterol), liver total cholesterol (TC), and TG levels. Additionally, it alleviates hepatic steatosis, inflammation, and fibrosis. THR-β agonist 11 is applicable in the study of MASH and other fibrotic diseases.
Product Specifications
CAS Number
3051970-23-8
Smiles
C (OC1=CC (C) =C (CC=2C=C (C (C) C) C (=O) NN2) C (C) =C1) P3 (=O) O[C@@H] (CCO3) C4=CC (Cl) =CC=C4
Molecular Formula
C26H30ClN2O5P
Molecular Weight
516.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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