Apoptosis inducer 45

Apoptosis inducer45 is an apoptosis inducer demonstrating cytotoxic activity against the MCF-7 cell line. It initiates apoptosis in these cells via the mitochondrial pathway by increasing the Bax/Bcl-2 ratio, leading to the cleavage of caspase-9 and subsequent fragmentation of the DNA repair protein PARP. Additionally, Apoptosis inducer45 induces the cleavage of caspase-8, which subsequently triggers the cleavage of caspase-3 and its downstream target PARP, resulting in extrinsic apoptosis. This compound is applicable in breast cancer research.