CHNQD-01281
CHNQD-01281 is a derivative of Brefeldin A and acts as an EGFR regulator. It exhibits potent antiproliferative activity against cancer cells, with IC50 values of 0.079 μM and 0.081 μM for T24 and J82 cells, respectively. CHNQD-01281 modulates both the EGFR/PI3K/AKT and EGFR/ERK pathways, influencing chemotactic effects on immune effector cells. It significantly inhibits tumor growth in T24 xenograft mouse models and extends survival in MB49 allograft mouse models by inducing cytotoxic T cell infiltration.
Product Specifications
CAS Number
2762488-97-9
Smiles
O (C (/C=C/C=1C=CC=NC1) =O) [C@H]/2[C@]3 ([C@@] (C[C@H] (O) C3) (/C=C/CCC[C@H] (C) OC (=O) \C=C2) [H]) [H]
Molecular Formula
C24H29NO5
Molecular Weight
411.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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