PD-166285
PD-166285 is an inhibitor of PKMYT1 with an IC50 value of 17 nM. It exhibits potent antiproliferative effects on CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM) . PD-166285 can induce apoptosis and cause CCNE1-amplified HCC1569 cells to arrest at the G1/S phase of the cell cycle. This compound is applicable for research on PKMYT1-targeted CCNE1-amplified cancers.
Product Specifications
CAS Number
717094-37-6
Smiles
O=C1C (=CC=2C=NC (=NC2N1C) NC3=CC=C (OCCN (C) C) C=C3) C4=C (Cl) C=CC=C4Cl
Molecular Formula
C24H23Cl2N5O2
Molecular Weight
484.38
Storage Conditions
-20°C
Notes
For research use only.
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