RSK2/TOP2-IN-1

RSK2/TOP2-IN-1 is a dual inhibitor targeting RSK2 and TOP2 enzymes. It specifically targets critical enzymes related to tumor progression, including ribosomal S6 kinase (RSK2) and topoisomerases (TOP2) IIα/IIβ. The compound demonstrates a selectivity index greater than 2 across all squamous cell carcinoma (SCC) cell lines. RSK2/TOP2-IN-1 induces apoptosis, autophagy, and the production of reactive oxygen species (ROS) . It is applicable in cancer research, particularly for squamous cell carcinoma.