Antiparasitic agent-29

Antiparasitic agent-29 (Compound 5) is a trypanosome alternative oxidase (TAO) inhibitor with an IC50 of 1.3 nM in Trypanosoma brucei. It exhibits broad-spectrum antiparasitic activity against Trypanosoma and Leishmania species. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting their energy metabolism, and displays strong membrane perturbation activity without cross-resistance. It is useful for research on parasitic diseases such as surra and dourine.