NSC 850745

NSC 850745 is a selective and potent inhibitor of c-Met/STAT3, with IC50 values of 210 nM and 670 nM, respectively. It inhibits cell proliferation, induces G2/M phase arrest, and triggers apoptosis (cell death) . NSC 850745 downregulates the expression of AKT-1, VEGF, and Bcl-2, while modulating p53, Bax, and caspase levels. This compound is utilized in cancer research, including studies on leukemia and colon cancer.