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PX20350

PX20350 is an FXR agonist with EC50 values of 83 nM for mFXR and 10 nM for hFXR. It significantly induces NDRG2 mRNA expression. PX20350 effectively inhibits the growth and metastasis of liver tumor cells (SK-GI-18 cells) and exhibits antitumor activity in orthotopic xenograft mouse models.

Product Specifications

CAS Number

1198085-23-2

Smiles

O=C (O) C1=CC=C (C=C1) CN (C2=CC=C (N=C2C (F) (F) F) OCC=3C (=NOC3C4CC4) C=5C (Cl) =CC=CC5Cl) C

Molecular Formula

C28H22Cl2F3N3O4

Molecular Weight

592.4

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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