PX20350
PX20350 is an FXR agonist with EC50 values of 83 nM for mFXR and 10 nM for hFXR. It significantly induces NDRG2 mRNA expression. PX20350 effectively inhibits the growth and metastasis of liver tumor cells (SK-GI-18 cells) and exhibits antitumor activity in orthotopic xenograft mouse models.
Product Specifications
CAS Number
1198085-23-2
Smiles
O=C (O) C1=CC=C (C=C1) CN (C2=CC=C (N=C2C (F) (F) F) OCC=3C (=NOC3C4CC4) C=5C (Cl) =CC=CC5Cl) C
Molecular Formula
C28H22Cl2F3N3O4
Molecular Weight
592.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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