CS47
CS47 is a reversible inhibitor of thioredoxin reductase 1 (TrxR1) . It activates stress-responsive glutathione (GSH) and iron regulatory pathways, leading to GSH depletion. This results in reactive oxygen species (ROS) accumulation, promoting HO-1 overexpression and causing intracellular iron overload, which ultimately induces ferroptosis in lung cancer not dependent on the KRAS gene. CS47 exhibits anticancer activity with low cytotoxicity to normal lung fibroblasts.
Product Specifications
CAS Number
1372792-51-2
Smiles
ClC=1N=C[N-] ([Au+][P] (C=2C=CC=CC2) (C=3C=CC=CC3) C=4C=CC=CC4) C1Cl
Molecular Formula
C21H16AuCl2N2P
Molecular Weight
595.21
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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