Chloroxoquinoline

Chloroxoquinoline is an anticancer agent that disrupts the DNA template of cancer cells, leading to DNA breaks and cell death. It inhibits cell invasion by downregulating the Rho/Rho kinase signaling pathway. In tumor-bearing mouse models, Chloroxoquinoline enhances the radiosensitivity of Lewis lung carcinoma cells and xenograft tumors. However, its long-term efficacy is reduced in rat models due to self-induction of CYP1A and CYP3A. Chloroxoquinoline exhibits broad-spectrum anticancer activity against non-small cell lung cancer (NSCLC), breast cancer, and gastric cancer.