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MBL-II-141

MBL-II-141 is a potent ABCG2 inhibitor with an IC50 of 0.11 μM. It inhibits the transport function of ABCG2 in a non-competitive manner, preventing ABCG2 from expelling substrates (such as Irinotecan) out of cells, thereby increasing the intracellular accumulation of the drug. MBL-II-141 does not affect ABCB1 (P-gp) or ABCC1 (MRP1) and exhibits very low cytotoxicity (IG50 > 100 μM) . This compound is useful for studying tumor multidrug resistance (MDR) .

Product Specifications

CAS Number

1353747-12-2

Smiles

O=C1C=C (OC2=CC=CC (OCC3=CC=C (Br) C=C3) =C12) C (=O) NCCC4=CNC=5C=CC (OC) =CC54

Molecular Formula

C28H23BrN2O5

Molecular Weight

547.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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