MSC778
MSC778 is a selective and orally active inhibitor of flap endonuclease 1 (FEN1), with an IC50 of 3 nM and a KD of 2.9 nM. It exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively targets BRCA2-deficient cells and enhances the tumor-stalling activity of Niraparib in BRCA2 KO DLD-1 mouse xenografts. It is applicable in colorectal cancer research.
Product Specifications
CAS Number
3098173-17-9
Smiles
O=C1C=2N (C[C@@]3 (N1CCOC3) [H]) N=C (O[C@@H] (C) C4=CC5=C (C=C4) C=CC (Cl) =C5) C (=O) C2O
Molecular Formula
C22H20ClN3O5
Molecular Weight
441.87
Storage Conditions
-20°C
Notes
For research use only.
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