NF-κB-IN-20

NF-κB-IN-20 is an orally bioavailable inhibitor of NF-κB. By binding directly to the Keap1 protein, NF-κB-IN-20 activates the Keap1/Nrf2/HO-1 antioxidant pathway and concurrently inhibits the NF-κB inflammatory pathway, working synergistically to reduce oxidative stress and inflammation. Additionally, NF-κB-IN-20 M11 suppresses the expression of IL-6, IL-1β, and TNF-α, significantly decreases ROS levels, and restores mitochondrial membrane potential. This compound is applicable in studies of acute lung injury (ALI) .