EYE-002

EYE-002 is an RPE65 inhibitor with an IC50 of 69 nM. It enhances the recovery of dark-adapted electroretinogram (ERG) a-/b-wave amplitudes in mice. EYE-002 regulates the visual cycle in mice by reducing 11-cisretinal (11cRAL) synthesis and increasing all-trans-retinyl esters (atREs) . It offers protective effects against light-induced retinal damage in mice. EYE-002 is valuable for research on retinal disorders related to the visual cycle, such as Stargardt disease type 1 (STGD1) .